CD-MS methods offer comprehensive AAV analytics, including:

✵    Assessments of empty, partial, and full capsid ratios

✵    Analysis of viral protein ratios

✵    DNA packaging analysis

Applicable to a variety of samples:

✵    Upstream cell lysates

✵    Purified downstream products

High-resolution mass and charge measurements can analyze:

✵   mRNA

✵   Plasmids

✵   Single-stranded DNA (ssDNA)

✵   Double-stranded DNA (dsDNA)

✵   DNA nanostructures

Capable of detecting:

✵    Genome truncations

✵    Structural analysis

CD-MS analysis can:

✵   Resolve assembly intermediates

✵   Quantify intact assembly products of Virus-Like Particles (VLPs)

Leveraging CD-MS results allows researchers to:

✵   Optimize VLP methods for uniform assembly of end product structures

Broad mass range of CD-MS enables:

✵   Assessment of empty/full ratios in large viral vectors

CD-MS assays are developed for:

✵  Characterizing the structure and stoichiometry of antigen in drug product

✵  Probing antibody binding affinity to target antigen

✵  Investigating the stability of vaccine antigens from pre-formulation to final products

Advantages of CD-MS include:

✵   High-throughput capabilities

✵   Broad scan range for effective analysis of complex mixtures

Mass and charge measurements offer insights into:

✵    Density of non-viral nanoparticles

✵    Polydispersity of non-viral nanoparticles

Mass analysis can be used to:

✵    Quantify particle conjugation

✵    Assess loading effectiveness